Study of endocrinological complications in children with beta thalassemia major

Background: Thalassemia is the commonest hemoglobinopathy in our country of which β thalassemia most common. More and more endocrinological complications are seen current scenario children usually than 10 years age with significant iron overload due to inadequate chelation. Aim study understand common key factors for their prevention.Methods: A prospective analytical was done at a tertiary care centre, civil hospital, Ahmedabad between 9-18 over period 1 month determine prevalence correlation mean serum ferritin levels beta patients.Results: Total 48 enrolled during period. Mean level 3179±788 ng/ml. Out 48, 20 (41.66%) having complications. Most commonly observed complication growth retardation 17 (35.41%) were undernourished 13 (27%) found have stunted growth. Delayed puberty 7 (14.58%). Hypothyroidism 4 (8.33%). Five patients (23.8%) <2500 ng/ml 15 (55.5%) beyond 2500 developed statistically (p=0.02).Conclusions: Endocrinological adolescent major mild severity when went Thus, these should be managed centre. Early identification multidisciplinary treatment necessary early as well prevention